OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function allele shortens life span. Some alleles have life span equal to wild type. daf-16 is required for life span extension by mutation of daf-2 or age-1 (Kenyon et al., 1993). Overexpression of daf-16 modestly increases life-span (~20%) (Henderson and Johnson, 2001)
Gene FunctionForkhead transcription factor (Lin et al., 1997).
Other Phenotypesdaf-16 mutants are dauer defective (Riddle et al., 1981). Mutation of daf-16 completely suppresses all the phenotypes of daf-2 and age-1 mutants, including life span extension, dauer arrest, reduced fertility, and viability defects (Kenyon et al. 1993; Larsen et al. 1995; Dorman et al. 1995; Tissenbaum and Ruvkun, 1998). daf-16 mutations suppress the long life span of the amphid neuron mutations (Apfeld and Kenyon 1999). daf-16 mutations also suppress life span extension of animals that have a germ line ablation (Hsin and Kenyon 1999). Sex-specific life span potential requires daf-16 (Gems and Riddle, 2000)
HomologsS.c. HCM1, FKH2, FKH1, FHL1
S.p. Spac1142.08, sep1, Spbc16G5.15c, mei4
C.e. C25A1.2, F40H3.4, K03C7.2, pes-1, B0286.5, T14G12.4 ...
D.m. CG11152, fd64A, slp1, CG16899, croc, slp2 ...
R.n. Hnf3a, Fkhr, Rn.26546, Hnf3g, Rn.10665, Rn.10101 ...
M.m. Fkhr2, Fkhr1, Foxa1, Foxm, Foxg1, Foxc1 ...
Primary ReferenceKenyon, C., Chang, J., Gensch, E., Rudner, A., and Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-4. [Abstract]
Other ReferencesLarsen, P. L., Albert, P. S., and Riddle, D. L. (1995). Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-83. [Abstract]
Lin, K., Dorman, J. B., Rodan, A., and Kenyon, C. (1997). daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-22. [Abstract]
Riddle, D. L., Swanson, M. M., and Albert, P. S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-71. [Abstract]
Tissenbaum, H. A., and Ruvkun, G. (1998). An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717. [Abstract]
Vanfleteren, J. R. (1993). Oxidative stress and aging in Caenorhabditis elegans. Biochem. J. 292, 605-608. [Abstract]
Henderson, S. T., and Johnson, T. E. (2001). daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11, 1975-80. [Abstract]
Relevant LinksWormPD:
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, transcription factor, dauer, metabolism, caloric restriction