NameCTT1
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeShortened life-span
Allele TypeOverexpression
StrainDBY746
DescriptionOverexpression of CTT1 alone in results in a slight decrease in stationary phase survival (Fabrizio et al., 2003).
Gene FunctionCytosolic catalase T.
Other PhenotypesOverexpression of CTT1 in combination with overexpression of SOD1 increases stationary phase survival by about 10% (Fabrizio et al., 2003).
HomologsS.p. CTA1
S.c. CTA1
M.m. CAT
D.m. CAT
R.n. CAT
H.s. CAT
C.e. CTL-2, CTL-1
M.m. CAT
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=CTT1
KeywordsKeywords yeast, stationary phase survival, Saccharomyces, cerevisiae, oxidative stress, mitochondria, respiraction, electron transport, reactive oxygen species, ROS, antioxidant