NameDTS-3
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainSamarkand
DescriptionFemale, but not male, DTS-3 heterozygous mutants display a 42% increase in mean life-span at 29 degrees C (Simon et al., 2003).
Gene FunctionInvolved in ecdysone biosynthesis.
Other PhenotypesDTS-3 +/- female adults have a 50% reduced ecdysone titer and reduced fertility (Simon et al., 2003). Female, but not male, heterozygotes also displayed a temperature-dependent increase in starvation resistance.
Mutation of the ecdysone receptor, EcR also increases longevity.
Homologs
Primary ReferenceSimon, A. F., Shih, C., Mack, A., and Benzer, S. (2003). Steroid control of longevity in Drosophila melanogaster. Science 299, 1407-10.
Other References
Relevant LinksFlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0002416
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=249462
Keywordsfly, hormone, steroid, signaling, fertility