NameEcR
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainCanton-S, cn bw
DescriptionFlies heterozygous for mutant alleles of EcR live approximately 45% longer (mean life-span) than wild-type flies (Simon et al., 2003).
Gene FunctionEcdysone receptor.
Other PhenotypesHomozygous mutantion of EcR is inviable. Development time and weight of EcR +/- flies was the same as control animals, however resistance to temperature, oxidative stress, and starvation was increased in the heterozygotes (Simon et al., 2003).
Mutation of DTS-3, a gene involved in ecdysone biosynthesis has a similar effect on longevity in female flies (Simon et al., 2003).
HomologsR.n. LXRA, NR1H4, VDR
M.m. LXRA, NR1H4, VDR, THRA
H.s. LXRA, NR1H4, THRA, VDR
Primary ReferenceSimon, A. F., Shih, C., Mack, A., and Benzer, S. (2003). Steroid control of longevity in Drosophila melanogaster. Science 299, 1407-10.
Other References
Relevant LinksFlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0000546
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=35540
Keywordsfly, hormone, steroid, signaling, fertility