NameSOD1
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainEG103
DescriptionOverexpression of SOD1 in combination iwth overexpression of SOD2 increases stationary phase survival by 30% (Fabrizio et al., 2003).
Gene FunctionCytosolic copper-zinc superoxide dismutase.
Other PhenotypesDeletion of SOD1 decreases survival in stationary phase (Longo et al., 1996).
Deletion of SOD1 causes sensitivity to hyperoxia as well as methionine and lysine auxotrophies (Longo et al., 1997).
HomologsS.p. sod1
C.e. sod-1, C15F1.7, ZK430.3
D.m. sod1, CG9027, CG17753
R.n. Sod1, Sod3
M.m. Sod1, Ccsd, Sod3
H.s. SOD1, CCS, SOD3
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Other ReferencesLongo, V. D., Gralla, E. B., and Valentine, J. S. (1996). Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271, 12275-12280. [Abstract]
Longo, V. D., Ellerby, L. M., Bredesen, D. E., Valentine, J. S., and Gralla, E. B. (1997). Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol 137, 1581-1588. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=sod1
Keywordsyeast, stationary phase survival, Saccharomyces, cerevisiae, oxidative stress, mitochondria, respiraction, electron transport, reactive oxygen species, ROS