NameSOD2
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainEG103
DescriptionOverexpression of SOD2 in combination with overexpression of SOD1 increases stationary phase survival by 30% (Fabrizio et al., 2003).
Gene FunctionSOD2 codes for manganese superoxide dismutase of the mitochondrial matrix (Longo et al., 1999).
Other PhenotypesDeletion of SOD2 decreases survival in stationary phase (Longo et al., 1996).
HomologsS.p. Spac1486.01, Spbc3h7.04
D.m. sod2
C.e. sod-2, sod-3
R.n. Sod2
M.m. Sod2
H.s. SOD2
Primary ReferenceFabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Other ReferencesLongo, V. D., Gralla, E. B., and Valentine, J. S. (1996). Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271, 12275-80. [Abstract]
Longo, V. D., Liou, L. L., Valentine, J. S., and Gralla, E. B. (1999). Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365, 131-42. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=sod2
Keywordsyeast, stationary phase survival, Saccharomyces, cerevisiae, oxidative stress, mitochondria, respiraction, electron transport, reactive oxygen species, ROS