OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
DescriptionRNAi of the F57B10.3 gene extends life-span by 21% (Lee et al., 2003). Life-span extension by RNAi of F57B10.3 is suppressed by daf-16.
Gene FunctionPhosphoglycerate mutase.
Other PhenotypesF57B10.3 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase:
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm