NameF28B3.9
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2
DescriptionRNAi of the F28B3.5 gene extends life-span by 31% (Lee et al., 2003). Life-span extension by RNAi of F28B3.5 is suppressed by daf-16.
Gene Function1-acyl-glycerol-3-phosphate acetyltransferase
Other PhenotypesF28B3.5 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsFLJ11210, LPAAT-DELTA
S.c. YBR042, YDR018
S.p. Spbc428.14p, Spac1851.02p
C.e. F55A11.5, ZK40.1, T05H4.1
D.m. CG4729, CG4753, FU12
R.n. AGPAT4
M.m. AGPAT4 , AGPAT3
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=F28B3.9
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm