NameK01C8.7
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2
DescriptionRNAi of the K01C8.7 gene extends life-span by 20% (Lee et al., 2003). Life-span extension by RNAi of K01C8.7 is not suppressed by daf-16.
Gene FunctionMitochondrial carrier protein.
Other PhenotypesK01C8.7 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2002).
HomologsS.c. FLX1, YIL006, YEL006 ...
S.p. Flx1, Spac688.09, SPAC227.03c ...
C.e. T09F3.2, C47E12.2, K02F3.2 ...
D.m. CG8026, CG18317, CG2139 ...
R.n. PCSCL, SLC25A20, Slc25a14 ...
M.m. 2610043O12RIK, C330005L02RIK, Slc25a17 ...
H.s. MFTC, FLJ10618, SLC25A17 ...
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=K01C8.7
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm