NameF13G3.7
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2
DescriptionRNAi of the F13G3.7 gene extends life-span by 25% (Lee et al., 2003). Life-span extension by RNAi of F13G3.7 is suppressed by daf-16.
Gene FunctionSimilarity to yeast mitochondrial carrier.
Other PhenotypesF13G3.7 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsH.s. KIAA0446, SLC25A15, SLC25A13, SLC25A12, SLC25A18 ...
M.m SLC25A19, SLC25A15, SLC25A13, 1110030N17Rik(20%)
R.n. PCSCL, SLC25A1, SLC25A21
D.m. CG5805, CG8026, CG2139 ...
C.e. Y43C5B.3, R11.1, K01C8.7 ...
S.p. Spac328.09p, Spcc1442.03p, SPBC12D12.05c ...
S.c. PET8, ODC2, YGR257 ...
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=F13G3.7
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm