NameT06D8.6
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2
DescriptionRNAi of the T06D8.6 gene extends life-span by 55% (Lee et al., 2003). Life-span extension by RNAi of T06D8.6 is not suppressed by daf-16.
Gene FunctionCytochrome c heme lyase.
Other PhenotypesT06D8.6 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsS.p. Spac24c9.02c, Spbc26h8.12p
S.c. CYC3, CYT2
D.m. CG6022
M.m. HCCS
H.s. HCCS
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=T06D8.6
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm