Namedaf-12
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionRecessive loss of function mutation shortens life span but activity is required for extension of life span after germ line ablation (Hsin and Kenyon, 1999) and can extend a daf-2 mutant life span (Larsen et al., 1995).
Gene FunctionPredicted steroid hormone receptor, no known ligand. Required for dauer formation (Riddle et al., 1981)
Other PhenotypesMutant is dauer defective, heterochronic (Riddle et al., 1981). Mutation of daf-12 suppresses life span extension by a mutation in daf-28 (Malone et al., 1996). Some alleles of daf-12 show synthetic lethality with mutation of age-1 (Malone et al., 1996) or mutation of daf-2 (Vowels and Thomas, 1992).
HomologsC.e. NHR-48, NHR-8, RO9G11.2, nhr-3, sex-1, nhr-23 ...
D.m. Hr96, EcR, Hnf4, CG9310, CG7404, Hr46 ...
R.n. Vdr, Rn.42943, Esr2, Rn.23656, Thra1, Rn.42941 ...
M.m. Nr1i2, Vdr, Nr1i3, Nr1h4, Rarg, Esrra ...
H.s. NR1I2, VDR, LXRA, CAR, RIP14, RARB ...
Primary ReferenceHsin, H., and Kenyon, C. (1999). Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-6. [Abstract]
Larsen, P. L., Albert, P. S., and Riddle, D. L. (1995). Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-83. [Abstract]
Other ReferencesMalone, E. A., Inoue, T., and Thomas, J. H. (1996). Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143, 1193-205. [Abstract]
Riddle, D. L., Swanson, M. M., and Albert, P. S. (1981). Interacting genes in nematode dauer larva formation. Nature 290, 668-71. [Abstract]
Vowels, J. J., and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-23. [Abstract]
Relevant LinksWormPD: http://www.proteome.com/databases/WormPD/reports/daf-12.html
WormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=daf-12
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=181263
KeywordsCaenorhabditis, elegans, worm, insulin, signaling, transcription factor, dauer