OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
DescriptionRNAi of the B0261.4 gene extends life-span by 18% (Lee et al., 2003). Life-span extension by RNAi of B0261.4 is not suppressed by daf-16.
Gene FunctionMitochondrial ribosomal subunit.
Other PhenotypesB0261.4 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsH.s. MRPL47
S.c. MRP14
S.p. Spcc4g3.06c
D.m. RLC1
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase:
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm