NameW09C5.8
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainN2
DescriptionRNAi of the W09C5.8 gene extends life-span by 62% (Lee et al., 2003). Life-span extension by RNAi of W09C5.8 is not suppressed by daf-16.
Gene FunctionCytochrome c oxidase IV. Component of mitochodrial Complex IV.
Other PhenotypesW09C5.8 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsH.s. COX4I1, COX4I2
D.m. CG10664, CG10396
R.n. COX4A, COX4B
M.m. COX4A, COX4B
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/gene/gene?name=W09C5.8
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm