OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
DescriptionRNAi of the F26E4.9 gene extends life-span by 41% (Lee et al., 2003). Life-span extension by RNAi of F26E4.9 is not suppressed by daf-16.
Gene FunctionCytochrome c oxidase Vb. Component of mitochodrial Complex IV.
Other PhenotypesF26E4.9 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsS.p. COX4
S.c. COX4
D.m. CG11015, CG11043
R.n. COX5B
M.m. COX5B
H.s. COX5B
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase:
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm