OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
DescriptionRNAi of the T02H6.11 gene extends life-span by 46% (Lee et al., 2003). Life-span extension by RNAi of T02H6.11 is not suppressed by daf-16.
Gene FunctionUbiquinol-cytochrome b reductase subunit. Component of mitochodrial Complex III.
Other PhenotypesT02H6.11 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsH.s. UQCRB
S.c. QCR7
S.p. QCR7
D.m. CG17856, CG3560
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase:
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm