OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
DescriptionRNAi of the D2030.4 gene extends life-span by 43% (Lee et al., 2003). Life-span extension by RNAi of D2030.4 is not suppressed by daf-16.
Gene FunctionNADH coQ oxidoreductaseB18. Component of mitochodrial Complex I.
Other PhenotypesD2030.4 RNAi animals have lower ATP content and oxygen consumption (Lee et al., 2003).
HomologsD.m. CG5548
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase:
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm