Namelrs-2
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainN2
DescriptionAnimals carrying the lrs-2(mg312) allele have a life-span that is extended by 200% at 20 C and 30% at 25 C (Lee et al., 2003). Life-span extension by lrs-2 is daf-16 independent.
Gene FunctionMitochondrial leucyl-tRNA-synthetase.
Other Phenotypeslsr-2 animals have lower ATP content and oxygen consumption (Lee et al., 2003).
Homologs
Primary ReferenceLee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J., and Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33, 40-8. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/misc/etree?name=lrs-2&class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172499
Keywordsmitochondria, electron transport, respiration, oxidative stress, ATP, metabolism, worm