InterventionGrowth on kanamycin treated bacteria
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainN2
DescriptionGrowth of worms on kanamycin-killed bacteria rather than actively dividing bacteria has been reported to extend life-span by 30-40% (Garigan et al., 2002).
Gene Function
Other PhenotypesOther mechanisms of inhibiting the growth of the bacterial food source, including UV-irradiation or treatment with carbenicillin, also extend life-span, suggesting that some factor associated with bacterial growth and proliferation is detrimental to worm longevity (Garigan et al., 2002).
Homologs
Primary ReferenceGarigan, D., Hsu, A. L., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-12. [Abstract]
Other References
Relevant Links
Keywordsfood source, feeding, E. coli, antibiotic