InterventionGrowth on UV-killed bacteria
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainN2
DescriptionGrowth of worms on UV-killed bacteria rather than actively dividing bacteria has been reported to extend life-span by 16% (Gems and Riddle, 2000) and 30-40% (Garigan et al., 2002) in two different studies.
Gene Function
Other PhenotypesOther mechanisms of inhibiting the growth of the bacterial food source, including treatment with kanamycin or carbenicillin also extend life-span, suggeting that some factor associated with bacterial growth and proliferation is detrimental to worm longevity (Garigan et al., 2002).
Homologs
Primary ReferenceGems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Gems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Other ReferencesGarigan, D., Hsu, A. L., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-12. [Abstract]
Relevant Links
Keywordsfood source, feeding, E. coli, irradiation