OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionSurvival among male animals lacking SMP30 is 50% at 180 days compared to 100% among controls (N. Maruyama, unpublished data).
Gene FunctionSenescence marker protein-30 (SMP30) is a calcium-binding protein that decreases in an androgen-independent manner with aging and is suggested to protect cells from apoptosis (Ishigami et al., 2002).
Other PhenotypesSMP30-/- mutant mice were indistinguishable from their SMP30+/+ littermates in terms of development and fertilization capability (Ishigami et al., 2002). However, -/- animals were more susceptible to liver injury after treatment with anti-FAS antibody.
SMP30-/- hepatocytes cultured in vitro were found to be more susceptible to apoptosis induced by tumor necrosis factor-alpha (TNF-alpha) plus actinomycin D (ActD) than SMP30+/+ hepatocytes.
SMP-30 is expressed primarily in the liver where it suppresses cell proliferation (Ishigami et al., 2001) and regulates calcium homeostasis by enhancing plasma membrane calcium ion- pumping activity (Fujita et al., 1999).
HomologsR.n SMP30
H.s. SMP30
Primary ReferenceIshigami, A., Fujita, T., Handa, S., Shirasawa, T., Koseki, H., Kitamura, T., Enomoto, N., Sato, N., Shimosawa, T., and Maruyama, N. (2002). Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-me [Abstract]
Other ReferencesIshigami, T., Fujita, T., Simbula, G., Columbano, A., Kikuchi, K., Ishigami, A., Shimosawa, T., Arakawa, Y., and Maruyama, N. (2001). Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes. Pathol Int 51, 491-7. [Abstract]
Fujita, T., Shirasawa, T., and Maruyama, N. (1999). Expression and structure of senescence marker protein-30 (SMP30) and its biological significance. Mech Ageing Dev 107, 271-80. [Abstract]
Relevant LinksLocusLink:
Keywordsmouse, senescence, biomarker, calcium homeostasis, liver, hepatocytes