Nameced-3
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainN2
DescriptionThe ced-3(n1286) allele has no effect on life-span (Garigan et al., 2002).
Gene FunctionCaspase.
Other Phenotypesced-3(n1286) animals are defective for apoptosis.
HomologsD.m. ICE, DCP-1
R.n. CASP2, CASP1
M.m. CASP7, CASP3, CASP2, CASP6, CASP8 ...
H.s. CASP3, CASP7, CASP6, CASP2, CASP8 ...
D.m. ICE, DCP-1
Primary ReferenceGarigan, D., Hsu, A. L., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-12. [Abstract]
Other References
Relevant LinksWormBase: http://www.wormbase.org/db/seq/sequence?name=ced-3;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=178272
Keywordsworm, programmed cell death, apoptosis, signaling