OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeRNAi
DescriptionRNAi of hsf-1shortens median and maximum life-span by approximately 35% (Garigan et al., 2002).
Gene FunctionTranscription factor that regulates response to heat and oxidative stress.
Other PhenotypesHsf-1 RNAi animals show phenotypes associated with accelerated aging as assayed by Nomarski microscopy (Garigan et al., 2002).
Primary ReferenceGarigan, D., Hsu, A. L., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-12. [Abstract]
Other References
Relevant LinksWormBase:;class=Locus
Keywordspremature aging, worm, stress response, heat shock, oxidative stress