InterventionOxygen pretreatment
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionPretreatment of worms with 100% oxygen at 40 psi for 8 hours results in a 20% increase in mean life-span upon return to standard atmospheric conditions (Cysper and Johnson, 2002).
Gene FunctionN/A
Other PhenotypesOxygen pretreatment or transient heat shock are thought to extend C. elegans life-span by hormesis (Cysper and Johnson, 2002).
Primary ReferenceCypser, J. R., and Johnson, T. E. (2002). Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. J Gerontol A Biol Sci Med Sci 57, B109-14. [Abstract]
Other References
Relevant Links
Keywordsoxidative stress, antioxidant, ROS, reactive oxygen species, nematode, hormesis, stress response