Namecher
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainPdL x rtTA; Oregon-R x rtTA
DescriptionOverexpression of filamin from a doxycycline-inducible promoter results in a 7-9% increase in mean life-span (Landis et al., 2003).
Gene FunctionActin-binding protein.
Other PhenotypesFilamin is involved in cytokinesis and ring canal formation (Li et al., 1999; Sokol and Cooley, 1999).
Drosophila filamin binds to both Drosophila and human presenilins,and filamin interacts genetically with presenilin in Drosophila (Guo et al., 2000).
HomologsS.c. FIMB
R.n. PLE1, SPCP
M.m. AAC2, AAC3, SPCO
H.s. FLNA, AAC2, AAC3, SPCO
Primary ReferenceLandis, G. N., Bhole, D., and Tower, J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd, and CctI genes. Genome Biology 4, R8.
Other ReferencesLi, M. G., Serr, M., Edwards, K., Ludmann, S., Yamamoto, D., Tilney, L. G., Field, C. M., and Hays, T. S. (1999). Filamin is required for ring canal assembly and actin organization during Drosophila oogenesis. J Cell Biol 146, 1061-74. [Abstract]
Sokol, N. S., and Cooley, L. (1999). Drosophila filamin encoded by the cheerio locus is a component of ovarian ring canals. Curr Biol 9, 1221-30. [Abstract]
Guo, Y., Zhang, S. X., Sokol, N., Cooley, L., and Boulianne, G. L. (2000). Physical and genetic interaction of filamin with presenilin in Drosophila. J Cell Sci 113 Pt 19, 3499-508. [Abstract]
Relevant LinksFlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0014141
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=42066
Keywordsfly, cell structure,