NameFwd
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainPdL x rtTA; Oregon-R x rtTA
DescriptionOverexpression of fwd from a doxycycline-inducible promoter results in a 7-9% increase in mean life-span (Landis et al., 2003).
Gene Function1-phosphatidylinositol-4-kinase
Other PhenotypesFwd regulates actin organization and ring canal formation during germline cytokinesis (Brill et al., 2000).
Fwd catalyzes the first step in the synthesis of the key regulatory membrane phospholipid PIP2,which is generated from PIP by a PI 4,5-kinase.
HomologsS.c. PIK1, YP34, TEL1, ESR1
C.e. F35H12.3, age-1
S.p. YDGB, RAD3, TOR1
D.m. KAPC
R.n. P11B, PK3G, FRAP
M.m. P11G, P11A, P11D, PK3G, FRAP, ATM
H.s. PI4K, P11G, P11B, P11D, PK3G, FRAP
Primary ReferenceLandis, G. N., Bhole, D., and Tower, J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd, and CctI genes. Genome Biology 4, R8.
Other ReferencesBrill, J. A., Hime, G. R., Scharer-Schuksz, M., and Fuller, M. T. (2000). A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Development 127, 3855-64. [Abstract]
Relevant LinksFlybasehttp://www.flybase.org/.bin/fbidq.html?FBgn0004373
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=45374
Keywordsfly, signaling, cell structure