NameCct1
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainPdL x rtTA; Oregon-R x rtTA
DescriptionOverexpression of rdh from a doxycycline-inducible promoter results in a 6-8% increase in mean life-span (Landis et al., 2003).
Gene FunctionCTP:phosphocholine cytidylyltransferase
Other PhenotypesCct1 catalyzes the conversion of phosphocholine to CDP-choline and is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway (Cornell and Northwood, 2000).
HomologsS.c. PCT1, ECT1
S.p. ECT1
C.e. F08C6.2
R.n. PCYT1A, PCYT1B
M.m. PCYT1A, PCYT1B
H.s. PCYT1A, PCYT1B
Primary ReferenceLandis, G. N., Bhole, D., and Tower, J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd, and CctI genes. Genome Biology 4, R8.
Other ReferencesCornell, R. B., and Northwood, I. C. (2000). Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem Sci 25, 441-7. [Abstract]
Relevant LinksFlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0041342&resultlist=fbgn19107.data[0]
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=117353
Keywordsfly, signaling