NameCYR1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainA364A, PSY316
DescriptionThe cdc35-1 allele confers a 75% extension of replicative life-span at 25C (Lin et al., 2000). CYR1 appears to be in the same genetic pathway for longevity as SIR2 and NPT1 and has been suggested as a genetic model for caloric restriction (Lin et al., 2000).
Gene FunctionAdenylate cyclase. Generates cAMP in response to RAS activation.
Other PhenotypesNull mutant arrest at G1 phase is rescued by exogenous cAMP (Matsumoto et al., 1982). A transposon mutagenized allele of CYR1 results in a 90% increase in chronological life-span (stationary phase survival) ,resistance to hydrogen peroxide, and resistance to heat shock (Fabrizio et al., 2001).
HomologsS.c. PTC1, SDS22, NUD1
S.p. ptc3, ptc1
C.e. F43C1.1, LET-413, SOC-2
D.m. CG5462, CG5407, SCRIB
M.m. SUR8, LRRN1, IMG
H. s. LOC55914
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesFabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., and Longo, V. D. (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-90. [Abstract]
Matsumoto, K., Uno, I., Oshima, Y., and Ishikawa, T. (1982). Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 79, 2355-9. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=cyr1
Keywordscaloric restriction, metabolism, signaling, cell cycle, replicative senescence, S. cerevisiae, yeast, stationary phase, oxidative stress