NameVhaSFD
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainPdL x rtTA; Oregon-R x rtTA
DescriptionOverexpression of VhaSFD from a doxycycline-inducible promoter results in a 5-10% increase in mean life-span (Landis et al., 2003).
Gene FunctionRegulatory subunit of the vacuolar ATPase proton pump.
Other PhenotypesVhaSFD is involved in the acidificiation and energization of organelles.
HomologsS.c. VMA13
S.p. SPAC22H10.03C
C.e. T14F9.1
H.s. ATP6V1H
Primary ReferenceLandis, G. N., Bhole, D., and Tower, J. (2003). A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd, and CctI genes. Genome Biology 4, R8.
Other References
Relevant LinksFlybase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0027779&resultlist=fbgn28322.data[0]
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=34997
Keywordsfly, membrane, ATP