InterventionAntimycin A
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainN2 fer-15(b26); fem-1(hc17)
DescriptionTreatment with 0.1 uM antimycin A results in a 23% increase in mean life-span (Dillin et al., 2002).
Gene FunctionAntimycin A is an inhibitor of the mitochondrial electron transport chain complex III.
Other PhenotypesDecreased function in either of two complex III components, cyc-1 or isp-1, results in increased life-span (Dillin et al., 2002;
Primary ReferenceDillin, A., Hsu, A. L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-401. [Abstract]
Other References
Relevant Links
Keywordsmitochondria, oxidative stress, metabolism, worm, ATP, respiration, electron transport chain, oxidative stress, ROS