InterventionTryptophan Restriction
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionMice fed a tryptophan-restricted diet had a median life-span approximately 10% longer than control-fed mice (De Marte and Enesco, 1986).
Gene FunctionTryptophan is an essential amino acid.
Other PhenotypesTryptophan-restricted mice weighed about 30% less than control-fed animals (De Marte and Enesco, 1986).
Methionine restriction in rats has a similar effect on longevity and body weight as tryptophan restriction in mice (Orentreich et al., 1993). Trytophan restriction in rats has also been shown to extend life-span (Ooka et al., 1988).
Primary ReferenceDe Marte, M. L., and Enesco, H. E. (1986). Influence of low tryptophan diet on survival and organ growth in mice. Mech Ageing Dev 36, 161-71. [Abstract]
Other ReferencesOrentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J Nutr 123, 269-74. [Abstract]
Ooka, H., Segall, P. E., and Timiras, P. S. (1988). Histology and survival in age-delayed low-tryptophan-fed rats. Mech Ageing Dev 43, 79-98. [Abstract]
Relevant Links
Keywordscalorie restriction, caloric, diet, nutrition, amino acid, protein,