Namectl-1
OrganismCaenorhabditis elegans
Aging PhenotypeN/A
Allele TypeRecessive
StrainBristol N2
DescriptionThe original results (below) associating mutation of ctl-1 with increased life-span have been retracted (Taub et al., 2003). The relationship between catalase activity and life-span, if any, is currently unclear.

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Loss of function shortens life span to 77% of wild type animals. Mutants accumulate fluorescent material faster than wild type, suggesting accelerated aging. Ctl-1 mutation prevents life span extension by daf-2 or clk-1 (Taub et al., 1999).

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Gene FunctionCytosolic catalase.
Other PhenotypesMutation of ctl-1 reduces catalase activity by 50% (Taub et al., 1999).
HomologsS.c. CTA1, CTT1
S.p. CTA1
C.e.CTL-2, Y54G11A.6
D.m. CAT, CG9314
R.n. CAT
M.m. CAS1
H.s. CAT
Primary ReferenceTaub, J., Lau, J. F., Ma, C., Hahn, J. H., Hoque, R., Rothblatt, J., and Chalfie, M. (1999). A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature 399, 162-6. [Abstract]
Taub, J., Lau, J. F., Ma, C., Hahn, J. H., Hoque, R., Rothblatt, J., and Chalfie, M. (2003). A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature 421, 764. [Abstract]
Other ReferencesNone.
Relevant LinksWormbase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=ctl-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=259738
Keywordsmetabolism, oxidative stress, mitochondria, insulin, signaling, Caenorhabditis, elegans, worm