OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
DescriptionRNAi of nuo-2 by bacterial feeding increases life-span by 42% (Dillin et al., 2002). RNAi of nuo-2 during larval stages is necessary and sufficient for increased life-span. RNAi of nuo-2 only during adulthood fails to extend life-span.
Gene FunctionNADH/ubiquinone oxidoreductase. Component of the mitochondrial respiratory chain complex I.
Other PhenotypesRNAi of nuo-2 causes a reduced rate of growth to adulthood, reduced pharyngeal pumping, and reduced defecation and motility. ATP levels are reduced by 60- 80% in nuo-3 animals and body size is reduced (Dillan et al., 2002).
Mutation of daf-16 fails to prevent life-span extension by RNAi of nuo-2 and mutation of daf-2 further extends the life span of nuo-2 RNAi animals.
HomologsH.s. NDUFS3
Primary ReferenceDillin, A., Hsu, A. L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., and Kenyon, C. (2002). Rates of behavior and aging specified by mitochondrial function during development. Science 298, 2398-401. [Abstract]
Other References
Relevant Links
Keywordsmitochondria, oxidative stress, metabolism, worm, ATP, respiration, electron transport chain, oxidative stress, ROS