NameGH
OrganismRattus norvegicus
Aging PhenotypeLife-span extension
Allele TypeAntisense
StrainJcl:Wistar
DescriptionAnimals carrying a single copy of an anti-sense GH transgene (tg/-) lived on average 7-10% longer than non-transgenic (-/-) animals (Shimokawa et al., 2002). Animals carrying two copies of the transgene (tg/tg) had a slightly shorter life-span compared to -/- animals, suggesting that an optimal dosage of GH is necessary to achieve life-span extension and that too little GH has a detrimental effect on longevity.
Gene FunctionGrowth hormone.
Other Phenotypes(tg/tg) and (tg/-) animals are dwarfs and show reduced levels of serum IGF-1 (Shimokawa et al., 2002).
Several other mutations resulting in dwarfism and/or reduced IGF-1 levels have also been shown to extend life-span in rodents. These include mutations in GHR, GHRHR, Prop1, Pit1, and IGF1-R.
Homologs
Primary ReferenceShimokawa, I., Higami, Y., Utsuyama, M., Tuchiya, T., Komatsu, T., Chiba, T., and Yamaza, H. (2002). Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. Am J Pathol 160, 2259-65. [Abstract]
Other References
Relevant LinksLocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=24391
Keywordshormonal, signaling, insulin, dwarf, rat, pituitary,