NameCAT (2)
OrganismDrosophila melanogaster
Aging PhenotypeNo effect on life-span
Allele TypeOverexpression
StrainUnknown
DescriptionTargeted overexpression of CAT in the mitochondrial matrix has no effect on life-span at 25C and slightly shortens life-span at 29C (Mockett et al., 2003).
Gene FunctionCatalase is an antioxidant enzyme that converts hydrogen peroxide to water.
Other PhenotypesTargeted overexpression of CAT in the mitochondrial matrix results in increased resistance to endogenous hydrogen peroxide, paraquat, and cold stress (Mockett et al., 2003). No effect on metabolic rate, activity, or resistance to hypoxia was noted.

It has been previously reported that simultaneous overexpression of catalase and superoxide dismutase extends life-span in flies (Orr and Sohal, 1994).

HomologsS.c. CTA1, CTT1
S.p. cta1
C.e. Y54G11A.6, CTL-2, CTL-1
D.m. CG9314
R.n. CAT
M.m. CAT
H.s. CAT
Primary ReferenceMockett, R. J., Bayne, A. V., Kwong, L. K., Orr, W. C., and Sohal, R. S. (2003). Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity. Free Radic Biol Med 34, 207-17.
Other ReferencesOrr, W. C., and Sohal, R. S. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-30. [Abstract]
Relevant LinksFlyBase: http://www.flybase.org/.bin/fbidq.html?FBgn0000261
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=40048
Keywordsoxidative stress, fly, Drosophila, melanogaster, mitochondria