NameCIT2 _
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeOverexpression
StrainYPK9
DescriptionOverexpression of CIT2 has no effect on life-span (Kirchman et al., 1999).
Gene FunctionPeroxisomal citrate synthase.
Other PhenotypesDeletion of CIT2 has no effect on life-span (Kirchman et al., 1999).
HomologsS.c. CIT1
S.p. SPAC6C3.04
C.e. T20G5.2
D.m. CG3861, CG14740
H.s. CS
Primary ReferenceKirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
Other References
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=CIT2
KeywordsMetabolism, Mitochondria, replicative senescence, Saccharomyces, cerevisiae, peroxisomes