Nameclk-1
OrganismCaenorhabditis elegans
Aging PhenotypeShortened life-span
Allele TypeOverexpression
StrainBristol N2
DescriptionOverexpression of clk-1 increases mitochondrial activity and shortens life-span (Felkai et al., 1999).
Gene FunctionRequired for ubiquinone biosynthesis. Has strong similarity to the human ubiquinone biosynthesis protein COQ7 / clk-1.
Other PhenotypesDecreased clk-1 function increases adult life-span by 30% (Lakowski and Hekimi, 1996)..
HomologsS.c. CAT5
S.p. Spbc337.15c
D.m. COQ7
M.m. COQ7
H.s. COQ7
Primary ReferenceFelkai, S., Ewbank, J. J., Lemieux, J., Labbe, J. C., Brown, G. G., and Hekimi, S. (1999). CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO Journal 18, 1783-1792. [Abstract]
Other ReferencesLakowski, B., and Hekimi, S. (1996). Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 1010-3. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=clk-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=175729
Keywordsmetabolism, signaling, mitochondria, Caenorhabditis, elegans, worm, coenzyme Q, development, rhytmic behaviors