InterventionNicotinic Acid
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeN/A
StrainW303, PSY316
DescriptionSupplementation of media with 5 mM or 50 mM nicotinic acid has no detrimental effect on life-span (Bitterman et al., 2002).
Gene Function
Other PhenotypesUnlike nicotinamide, nicotinic acid does not inhibit the NAD-dependent histone deacetylase activity of SIR2.
Primary ReferenceBitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., and Sinclair, D. A. (2002). Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem 277, 45099-107. [Abstract]
Other References
Relevant Links
Keywordssilencing, histone, deacetylase, NAD, calorie, caloric, restriction