InterventionDiphenylhydantoin
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainC3H/Sn
DescriptionChronic treatment of female C3H/Sn mice with diphenylhydantoin (2 mg/day) prolonged mean life-span by 25% (Dilman and Anisimov, 1980).
Gene FunctionAnti-epileptic drug
Other PhenotypesDiphenylhydantoin treated animals had a 2.3-fold decrease in tumors (Dilman and Anisimov, 1980).
Homologs
Primary ReferenceDilman, V. M., and Anisimov, V. N. (1980). Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology 26, 241-6. [Abstract]
Other References
Relevant Links
Keywordscancer