OrganismPodospora anserina
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionDisruption of the nuclear COX5 gene delayed senescence, increasing longevity between 7- and 15-fold in the 30 isolates tested (Dufour et al., 2000). Onset of senescence was not accompanied by the accumulation of senescence-specific mtDNA molecules (Dufour et al., 2000).
Gene FunctionCOX5 codes for subunit V of the cytochrome c oxidase complex (Dufour et al., 2000).
Other PhenotypesDeletion of PaCOX5 results in exclusive use of the alternative respiratory pathway and a decrease in production of reactive oxygen species (Dufour et al., 2000). Moreover, accumulation of several senescence-specific mitochondrial DNA molecules is prevented in this nuclear mutant (Dufour et al., 2000)
HomologsS.c. COX5a, COX5b
S.p. Spcc338.10c
Primary ReferenceDufour, E., Boulay, J., Rincheval, V., and Sainsard-Chanet, A. (2000). A causal link between respiration and senescence in Podospora anserina. Proc Natl Acad Sci U S A 97, 4138-43. [Abstract]
Other ReferencesN/A
Relevant LinksN/A
KeywordsPodospora anserina, metabolism, oxidative stress, mitochondria