OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionMutation increases life-span by approximately 15-20% (Yang and Wilson 1999). An age-1 age-2 double mutant strain lives longer than either single mutant and exhibits a longer life-span at 25C than at 20C.
Gene FunctionUnknown. Gene has not been mapped or cloned.
Other PhenotypesMutant exhibits normal motility and reduced fertility (Yang and Wilson, 1999).
Primary ReferenceYang, Y., and Wilson, D. L. (1999). Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 54, B137-42. [Abstract]
Other ReferencesNone.
Relevant LinksWormBase:
KeywordsCaenorhabditis, elegans, worm