Nameage-2
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionMutation increases life-span by approximately 15-20% (Yang and Wilson 1999). An age-1 age-2 double mutant strain lives longer than either single mutant and exhibits a longer life-span at 25C than at 20C.
Gene FunctionUnknown. Gene has not been mapped or cloned.
Other PhenotypesMutant exhibits normal motility and reduced fertility (Yang and Wilson, 1999).
HomologsN/A
Primary ReferenceYang, Y., and Wilson, D. L. (1999). Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 54, B137-42. [Abstract]
Other ReferencesNone.
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=age-2
KeywordsCaenorhabditis, elegans, worm