InterventionPhenformin
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainC3H/Sn
DescriptionChronic treatment of female C3H/Sn mice with phenformin (2 mg/day) increased mean life span by 23% (Dilman and Anisimov, 1980) .
Gene FunctionAnti-diabetic drug.
Other PhenotypesPhenformin treatment reduced the incidence of tumors 4-fold (Dilman and Anisimov, 1980).
Homologs
Primary ReferenceDilman, V. M., and Anisimov, V. N. (1980). Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology 26, 241-6. [Abstract]
Other References
Relevant Links
Keywordsdiabetes, blood glucose, insulin, cancer