Interventiondeprenyl
Alternate Nameselegiline
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainB6D2F1 (C57BL/6J x DBA/2J)F1 and B6CBAF1 (C57BL/6J x CBA/CaHT6J)F1
DescriptionSubcutaneous injection of 0.25 mg/kg L-deprenyl 3 times a week starting at mean ages of 26 months and 18.5 months increases life span by 6-9% in mice (Archer and Harrison, 1996). While none of the life span effects were significant for a single genotype and gender, life spans were significantly longer in L-deprenyl-treated animals (p = .011) when all data were combined.
Similar treatments have been found to increase life-span in rats, dogs, and hamsters. However, it should also be noted there are a number of reports of failure of (-)deprenyl treatment to extend life-span and shortening of lifespan by (-)deprenyl treatment has also been reported (reviewed in Kitani et al., 2002).
Gene FunctionMAO B (monoamine oxidase) inhibitor (Knoll, 1980).
Other PhenotypesL-deprenyl significantly reduced fecundity of male mice (Archer and Harrison, 1996). L-deprenyl-treated B6CBAF1 males and females were significantly heavier than controls after 4-6 months of treatment. There were no significant effects of L-deprenyl on measures of changes with age in the following biological systems: activity, excitement, red blood cell mass, collagen denaturation rate, and wound healing rate.
Homologs
Primary ReferenceArcher, J. R., and Harrison, D. E. (1996). L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J Gerontol A Biol Sci Med Sci 51, B448-53. [Abstract]
Other ReferencesKitani, K., Minami, C., Isobe, K., Maehara, K., Kanai, S., Ivy, G. O., and Carrillo, M. C. (2002). Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of vari [Abstract]
Relevant Links
Keywordsdeprenyl, selegiline, selegeline, dog, SOD, superoxide dismutase, CAT, catalase, oxidative stress, oxidative damage, radicals, cancer, tumor, spleen, immune, humoral