Alternate Nameselegiline
OrganismCanis lupus familiaris
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionAdministration of 1 mg/kg per day L-deprenyl to Beagle dogs for 2 years and 10 weeks signigicantly increased survival of dogs between 10 and 15 years old at the start of the study (Ruehl et al., 1997). Twelve of 15 (80%) dogs in the L-deprenyl group survived to the conclusion of the study, in contrast to only 7 of 18 (39%) of the dogs who received placebo (P=0.017). At the time the first L-deprenyl treated dog died on day 427, 5 placebo treated dogs had already succumbed, the first on day 295.
Similar treatments have been found to increase life-span in mice, rats, and hamsters. However, it should also be noted there are a number of reports of failure of (-)deprenyl treatment to extend life-span and shortening of lifespan by (-)deprenyl treatment has also been reported (reviewed in Kitani et al., 2002).
Gene FunctionMAO B (monoamine oxidase) inhibitor (Knoll, 1980)
Other Phenotypes
Primary ReferenceRuehl, W. W., Entriken, T. L., Muggenburg, B. A., Bruyette, D. S., Griffith, W. C., and Hahn, F. F. (1997). Treatment with L-deprenyl prolongs life in elderly dogs. Life Sci 61, 1037-44. [Abstract]
Other ReferencesKitani, K., Minami, C., Isobe, K., Maehara, K., Kanai, S., Ivy, G. O., and Carrillo, M. C. (2002). Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of vari [Abstract]
Relevant Links
Keywordsdeprenyl, selegiline, selegeline, dog, SOD, superoxide dismutase, CAT, catalase, oxidative stress, oxidative damage, radicals, cancer, tumor, spleen, immune, humoral