Interventiondeprenyl
Alternate Nameselegiline
OrganismMesocricetus auratus
Aging PhenotypeLife-span extension
Allele TypeN/A
Strainunknown
DescriptionFemale Syrian hamsters provided with 0.5 mg per kg body weight per day of deprenyl have a life-span that is extended by approximately 15% relative to controls (Stoll et al., 1997). The same treatment fails to significantly extend the life-span of male hamsters.
Similar treatments have been found to increase life-span in mice, rats, and dogs. However, it should also be noted there are a number of reports of failure of (-)deprenyl treatment to extend life-span and shortening of lifespan by (-)deprenyl treatment has also been reported (reviewed in Kitani et al., 2002).
Gene FunctionMAO B (monoamine oxidase) inhibitor (Knoll, 1980)
Other PhenotypesMAO-B was inhibited equally in both sexes by about 40%, although females had a higher baseline MAO-B activity (Stoll et al., 1997). No increase in MAO-B with age was observed. Female control hamsters had a shorter life span than male controls; however, this sex difference disappeared in the selegiline-treated animals.
Homologs
Primary ReferenceStoll, S., Hafner, U., Kranzlin, B., and Muller, W. E. (1997). Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males. Neurobiol Aging 18, 205-11. [Abstract]
Other ReferencesKnoll, J. (1980). Deprenyl (selegeline): the history of its development and pharmaceutical action. Acat Neurol Scand Suppl 95, 57-80.
Kitani, K., Minami, C., Isobe, K., Maehara, K., Kanai, S., Ivy, G. O., and Carrillo, M. C. (2002). Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of vari [Abstract]
Relevant LinksR.n. depre: http://sageke.sciencemag.org/cgi/genedata/sagekeGdbIntrvn;257
Keywordsselegiline, selegeline, SOD, superoxide dismutase, CAT, catalase, oxidative stress, oxidative damage, radicals, cancer, tumor, spleen, immune, humoral