Intervention2-mercaptoethanol
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainBC3F1
DescriptionAnimals fed a diet supplemented with 2-mercaptoethanol (2-ME) demonstrate an increased mean and maximum life-span (Heidrick et al., 1984).
Gene Function2-mercaptoethanol is an antioxidant.
Other PhenotypesT-cell-dependent immune responses were higher in the 2-ME-fed mice compared to the controls when the animals were young (Heidrick et al., 1984). The accumulation of fluorescent products of lipid peroxidation damage was also delayed in the lymphocytes of the 2-ME-fed mice and tumor onset and incidence was reduced in these animals.
Homologs
Primary ReferenceHeidrick, M. L., Hendricks, L. C., and Cook, D. E. (1984). Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice. Mech Ageing Dev 27, 341-58. [Abstract]
Other References
Relevant Links
Keywordsantioxidant, free radicals, free radical theory of aging, mitochondria, immune response