InterventionEthoxyquin
Alternate Name
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainCH3
DescriptionAddition of 0.5% ethoxyquin to the diet of male and female CH3 mice results in an 20% increase in mean life-span but has no effect on maximum life-span (Comfort et al., 1971).
Gene FunctionEthoxyquin is an antioxidant.
Other PhenotypesAddition of an antioxidant mixture containing ethoxyquin and 2-MEA to the diet of calorically restricted mice shortened life-span approximately 20% (Harris, et al., 1990).
Homologs
Primary ReferenceComfort, A., Youhotsky-Gore, I., and Pathmanathan, K. (1971). Effect of ethoxyquin on the longevity of C3H mice. Nature 229, 254-5. [Abstract]
Other ReferencesHarris, S. B., Weindruch, R., Smith, G. S., Mickey, M. R., and Walford, R. L. (1990). Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice. J Gerontol 45, B141-7. [Abstract]
Relevant Links
Keywordsantioxidant, free radicals, free radical theory of aging, mitochondria, caloric restriction, calorie