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| | Intervention | 2-mercaptoethylamine hydrochloride |
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| Alternate Name | 2-MEA |
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| Organism | Mus musculus |
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| Aging Phenotype | Life-span extension |
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| Allele Type | N/A |
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| Strain | LAF |
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| Description | Addition of 1% by weight 2-MEA to the diet of male LAF mice, started shortly after weaning, increases average life-span by approximately 30%. This regimen has no effect on maximum life-span. (Harman, 1968; Harman, 2001). |
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| Gene Function | 2-MEA is an antioxidant |
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| Other Phenotypes | Addition of 2-MEA to the maternal diet of female mice increased the life-span of male and female offspring by 15% and 8%, respectively (Harman and Eddy, 1979; Harman, 2001). Addition of an antioxidant mixture containing ethoxyquin and 2-MEA to the diet of calorically restricted mice shortened life-span approximately 20% (Harris, et al., 1990). |
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| Homologs | |
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| Primary Reference | Harman, D. (1968). Free radical theory of aging: effect of free radical inhibitors on the mortality rate of LAF1 mice. J Gerontol 23, 476-82.
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| Other References | Harman, D. (2001). Aging: overview. Ann N Y Acad Sci 928, 1-21. [Abstract]
Harman, D., and Eddy, D. E. (1979). Free radical theory of aging: beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring: possible explanation of the sex difference in longevity. Age 2, 109-22.
Harris, S. B., Weindruch, R., Smith, G. S., Mickey, M. R., and Walford, R. L. (1990). Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice. J Gerontol 45, B141-7. [Abstract]
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| Relevant Links | |
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| Keywords | antioxidant, free radicals, free radiacal theory of aging, mitochondria, caloric restriction, calorie |
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