Intervention2-mercaptoethylamine hydrochloride
Alternate Name2-MEA
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionAddition of 1% by weight 2-MEA to the diet of male LAF mice, started shortly after weaning, increases average life-span by approximately 30%. This regimen has no effect on maximum life-span. (Harman, 1968; Harman, 2001).
Gene Function2-MEA is an antioxidant
Other PhenotypesAddition of 2-MEA to the maternal diet of female mice increased the life-span of male and female offspring by 15% and 8%, respectively (Harman and Eddy, 1979; Harman, 2001). Addition of an antioxidant mixture containing ethoxyquin and 2-MEA to the diet of calorically restricted mice shortened life-span approximately 20% (Harris, et al., 1990).
Primary ReferenceHarman, D. (1968). Free radical theory of aging: effect of free radical inhibitors on the mortality rate of LAF1 mice. J Gerontol 23, 476-82.
Other ReferencesHarman, D. (2001). Aging: overview. Ann N Y Acad Sci 928, 1-21. [Abstract]
Harman, D., and Eddy, D. E. (1979). Free radical theory of aging: beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring: possible explanation of the sex difference in longevity. Age 2, 109-22.
Harris, S. B., Weindruch, R., Smith, G. S., Mickey, M. R., and Walford, R. L. (1990). Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice. J Gerontol 45, B141-7. [Abstract]
Relevant Links
Keywordsantioxidant, free radicals, free radiacal theory of aging, mitochondria, caloric restriction, calorie