InterventionMethionine restriction
Alternate Name
OrganismRattus norvegicus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainFischer 344
DescriptionRestriction of L-methionine from 0.86% to 0.17% of the diet results in a 30% increase in life-span (Orentreich et al., 1993). In a subsequent experiment, methionine restriction resulted in a 42% increase in mean and 44% increase in maximum life-span.
Gene FunctionL-methionine is an essential amino acid.
Other PhenotypesMethionine restriction resulted in a 43% lower body weight compared to controls (Richie et al, 1994), although food intake was actually greater on a body weight basis in restricted animals. Serum glutathione levels were increased 80-140% in methionine restricted animals.
Tryptophan restriction in mice or rats has a similar effect on longevity as methionine restriction in rats (De Marte and Enesco, 1986; Ooka et al., 1988).
Homologs
Primary ReferenceOrentreich, N., Matias, J. R., DeFelice, A., and Zimmerman, J. A. (1993). Low methionine ingestion by rats extends life span. J Nutr 123, 269-74. [Abstract]
Other ReferencesRichie, J. P., Jr., Leutzinger, Y., Parthasarathy, S., Malloy, V., Orentreich, N., and Zimmerman, J. A. (1994). Methionine restriction increases blood glutathione and longevity in F344 rats. Faseb J 8, 1302-7. [Abstract]
Richie, J. P., Jr., Leutzinger, Y., Parthasarathy, S., Malloy, V., Orentreich, N., and Zimmerman, J. A. (1994). Methionine restriction increases blood glutathione and longevity in F344 rats. Faseb J 8, 1302-7. [Abstract]
De Marte, M. L., and Enesco, H. E. (1986). Influence of low tryptophan diet on survival and organ growth in mice. Mech Ageing Dev 36, 161-71. [Abstract]
Ooka, H., Segall, P. E., and Timiras, P. S. (1988). Histology and survival in age-delayed low-tryptophan-fed rats. Mech Ageing Dev 43, 79-98. [Abstract]
Relevant Links
Keywordscalorie restriction, caloric, diet, nutrition, amino acid, protein,