OrganismPodospora anserina
Aging PhenotypeLife-span extension
Allele TypeDeletion
DescriptionDeletion of mobile group II intron (intron alpha) from COX1 doubled lifespan (Begel et al., 1999). Deletion encompassing intron alpha and its upstream exon abolished the senescence process entirely (Koll et al., 1985).
Gene FunctionCOX1 codes for subunit I of the cytochrome c oxidase complex (Begel et al., 1999).
Other PhenotypesDeletion of the PaCOX1 intron-alpha prevented accumulation of senescence-associated DNA concatemer corresponding to this region of the mitochondrial genome (Begel et al., 1999)
HomologsS.c. COX1, AI5, AI2, AI3
S.p. cox1, cox1i1
C.e. COX1
R.n. COX1
M.m. MT-CO1
H.s. MTCO1
Primary ReferenceBegel, O., Boulay, J., Albert, B., Dufour, E., and Sainsard-Chanet, A. (1999). Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina. Mol Cell Biol 19, 4093-100. [Abstract]
Koll, F., Belcour, L., and Vierny, C. (1985). A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures. Plasmid 14, 106-17. [Abstract]
Other ReferencesSainsard-Chanet, A., Begel, O., and Belcour, L. (1993). DNA deletion of mitochondrial introns is correlated with the process of senescence in Podospora anserina. J Mol Biol 234, 1-7. [Abstract]
Relevant LinksN/A
KeywordsPodospora, anserina, metabolism, mitochondria, oxidative stress